PhD position: Blood vessels and dementia
Amsterdam UMC, Netherlands
- Institution
- Amsterdam UMC
- Country
- Netherlands
- Position type
- PhD
- Application deadline
- 15 October 2026
- Funding
- Fully funded position
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About this position
Job description
The glymphatic system consists of channels surrounding the blood vessels. Through these channels, substances move into and out of the brain. In various forms of dementia, disease processes affecting the cerebral vascular bed play an important role.
Reduced blood flow, leakage of the blood-brain barrier and the accumulation of harmful proteins often occur together. In this project, we test the hypothesis that leakage of the blood-brain barrier disrupts the glymphatic system. This may accelerate the aggregation of amyloid beta in and around blood vessels, a condition known as cerebral amyloid angiopathy (CAA).
Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page.
In this project, you will conduct preclinical studies using animal models, including a model for human CAA. You will investigate whether the blood-brain barrier is disrupted in this model and whether interventions targeting the blood-brain barrier influence the course of CAA.
You will use a range of techniques to study these processes, including:
- MRI;
- immunostaining;
- confocal microscopy;
- ex vivo assays on blood vessels.
Apply directly to Amsterdam UMC
Emerging Scholars Council is not the employer and does not recruit for this position. It is advertised by Amsterdam UMC, and your application goes to them. We help students prepare and strengthen their applications.
Go to the official application page →Applications close 15 October 2026.