Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842

Postdoctoral Scientist
Salary: £42,694 per annum
Fixed term, 3 years
MRC Laboratory of Molecular Biology, Cambridge, UK

To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to develop methods for forming alpha-synuclein filaments with the same structures as those from human brain. This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB.

The assembly of alpha-synuclein into abnormal amyloid filaments is central to the development of several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. Since 2020, we have used electron cryo-microscopy (cryo-EM) to show that specific alpha-synuclein determine the structures of alpha-synuclein filaments from human brains. We have shown that specific filament folds define these diseases. Non-proteinaceous densities of unknown composition are also present. To understand mechanisms of disease, one must be able to form filaments that have the same structures as those from human brains in vitro, in cells and in animals. This may require the addition of cofactors of known identity. One successful candidate will use immunoprecipitation and mass spectrometry to identify the chemical identity of cofactors (in collaboration with Professor P. Barran, University of Manchester), The second candidate will develop methods for making alpha-synuclein folds like those from human brains and use cryo-EM to analyse these folds.    

The successful candidate will have experience in the generation of experimental models of amyloid formation and/or cryo-EM/cryo-ET. A PhD in a relevant subject or due to complete a PhD within 6 months is necessary. Good communication skills and the ability to work well both independently and in a group are crucial.

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

The LMB has a collaborative working culture and state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. We have a staff restaurant with roof terrace and access to a Campus nursery and sports and social facilities. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications. Further information about the benefits available can be found at http://www.discover.ukri.org/benefits-of-working-at-ukri.

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrclmb.ac.uk

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

Closing date: 11 October 2026

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrclmb.ac.uk.