Postdoctoral Training Scientist

MRC Postdoctoral Research Scientist in Gene Regulation and High-Throughput CRISPR screens

Genomic Variation and Disease Group

(3 Years fixed term)

MRC Band 4 Salary: £39,375 plus London allowances (£3,913 & £1,472) per annum*

 London, UK

A 3-year postdoctoral position is available at the MRC Laboratory of Medical Sciences (LMS) to work in the Genomic Variation and Disease Group headed by Doctor Lila Allou. The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation, the LMS has a collaborative working culture and a new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus. For more information, visit https://lms.mrc.ac.uk/research/genomic-variation-and-disease/ 

The Genomic Variation and Disease Group works at the intersection of medical genetics, bioinformatics, and molecular biology to explore the mechanisms underlying human diseases. The group uses CRISPR/Cas9 genome editing and synthetic genomics for mouse or human genome rewriting to model disease-causing chromosomal structural variants (SVs) and study their functional consequences. Our challenge is understanding how this type of genomic variation affects molecular and cellular processes to influence organismal phenotypes.

We are looking for a talented postdoctoral scientist with a background in molecular biology to join our team. As a key member, you will be part of our collaborative effort to study the molecular mechanisms underlying gene regulation and develop a scalable platform for engineering patient-specific structural variants. Your work will involve in vitro (cellular differentiation) and/or in vivo mouse models, CRISPR/Cas9 genome editing and high-throughput CRISPR screens, and single-cell technologies to investigate the molecular consequences of SVs impacting the noncoding genome.

At our newly established lab, we are committed to creating a welcoming and supportive environment where people of all backgrounds can thrive. We value diversity and collaboration and focus on conducting cutting-edge basic and translational science. We provide extensive on-the-job training as needed for the projects. At the LMS, we also offer excellent mentoring and support to help you reach your career goals. As a post holder, you will have the opportunity to work with an extensive network of collaborators, attend scientific conferences, and publish the results of your work in leading journals.

For full details of this post and to complete an online application, visit Postdoctoral Training Scientist - UKRI Careers and upload your CV, names, and contacts of two scientific references along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted. Please quote reference number LMS 2880.

Closing date: 4th October 2026

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply.

‘The MRC is an equal opportunities employer.

‘Leading Science for Better Health’

*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly installments. The Training Allowance increases to £1,300 in year two and £1,800 in the third year.