PhD candidate 'Modulating the tumor microenvironment to enhance radiosensitivity'
Radboud University Medical Center (Radboudumc), Netherlands
- Institution
- Radboud University Medical Center (Radboudumc)
- Country
- Netherlands
- Position type
- PhD
- Subject area
- Medicine & Health
- Application deadline
- 3 October 2026
- Funding
- Fully funded position
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About this position
Job description
The tumor microenvironment (TME) plays an important role in determining how tumors respond to radiotherapy. Features such as stromal composition, hypoxia, and cellular senescence can contribute to radioresistance and may therefore represent potential therapeutic targets.
In this PhD project, you will investigate how modulation of the TME can enhance the response to radiotherapy. The project will combine patient-derived models and in vivo tumor models to study how different TME characteristics contribute to treatment response and to explore potential strategies to target these mechanisms. A range of complementary preclinical approaches is used, including hypoxia modulation, targeting of senescent cells or cancer associated fibroblasts (CAFs), (image-guided) radiotherapy and immune checkpoint inhibition. Treatment response and underlying mechanisms will be assessed through readouts such as DNA damage and repair, tumor growth and characterization of the TME. The precise experimental approaches will be guided by the scientific findings and direction of the project.
Apply directly to Radboud University Medical Center (Radboudumc)
Emerging Scholars Council is not the employer and does not recruit for this position. It is advertised by Radboud University Medical Center (Radboudumc), and your application goes to them. We help students prepare and strengthen their applications.
Go to the official application page →Applications close 3 October 2026.