Postdoc - Hill Lab
The Francis Crick Institute, United Kingdom
- Institution
- The Francis Crick Institute
- Country
- United Kingdom
- Position type
- Postdoc
- Subject area
- Medicine & Health
- Salary
- GBP 47500.00–0.00 YEAR
- Location
- London, England, United Kingdom
- Funding
- Fully funded position
Want to be the strongest applicant for this position?
Book a free 15-minute call with our team. We will look at your profile against what The Francis Crick Institute is actually looking for, and tell you honestly where you stand and what to strengthen before you apply.
Book a free call about this position →No cost, no obligation. Mentors who have secured funded PhD positions themselves.
We mentor STEM applicants only. If your research aspirations are outside STEM subjects, you're very welcome to use this board and apply directly; we just aren't the right people to mentor you.
About this position
Location: The Francis Crick Institute, Midland Road, London
About us
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
To learn more about the Crick, click here.
About the role
The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Our work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes.
Click here to find out more about the Hill Lab
We are looking for a highly motivated postdoc with proven research abilities and excellent publication record to work on structural projects using Cryo-EM and crystallography to gain mechanistic insights into TGF-β family signalling in health and disease.
What you will be doing
We have very recently solved the structure of a complex comprising SKI–phosphorylated SMAD2–SMAD4, that sheds light on the effect of the SKI mutations on SKI–SMAD binding. One of the main ambitions of this new project is to understand now using structural, biochemical and biophysical approaches, how this complex is recognised by RNF111 for proteosomal degradation. We also want to understand how the full length activated SMAD complexes bind at the TGF-β/activin-responsive elements with cooperating transcription factors to activate transcription. We are investigating this for wild type SMADs, but also in the context of another disease, Myhre syndrome, where SMAD4 contains an activating mutation.
Click here for full job description
About you
You will bring:
- PhD in a relevant biological science, ideally in structural biology*
- Good knowledge and experience of Cryo-EM and crystallography*
- Technical expertise molecular biology, protein production, biophysical and biochemical techniques and structural analysis*
- Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals*
- Strong evidence of data presentation at scientific meetings
- Strong organisational skills and thorough record-keeping
- Ability to work independently and also in a team
Minimum criteria*
About Working at the Crick…
Our values
- We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
- We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
- We are collegial. We show respect for one another, work cooperatively and support the wider community.
At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact karen.au@crick.ac.uk.
To read more about our EDI approach, click here.
What will you receive?
We value our team members and are proud to offer an extensive range of benefits to support their well-being and development. You can find out more about what we offer here.
To apply for this role, please click on the 'Apply' button above.
Apply directly to The Francis Crick Institute
Emerging Scholars Council is not the employer and does not recruit for this position. It is advertised by The Francis Crick Institute, and your application goes to them. We help students prepare and strengthen their applications.
Go to the official application page →Contact listed in the advert
Some positions — especially in Germany, Austria and Switzerland — are filled by writing directly to the supervisor rather than through an online form. These addresses were taken from the advert text, so check them against the official listing before you write.
A cold email to a supervisor is the highest-leverage thing you can send — and the easiest to get wrong. Ask us to look at yours before you hit send.